rheumatic fever, rheumatic myocarditis, pericarditis , tendenit, bursitis, synovitis, and desertion . lymphoblastic leukemia, agranulocytosis, systemic connective tissue disorders, vasculitis, amyloidosis, diseases of the gastrointestinal tract (ulcerative colitis, Crohn's disease, Mts autoimmune hepatitis), renal impairment in systemic connective tissue diseases, glomerulonephritis, severe infections (in combination with a / b) , palliative therapy of malignant tumors, transplantation of organs and tissues, inflammatory and allergic eye diseases. hemolytic anemia, thrombocytopenia, G. Glucocorticoids. Contraindications to the use of drugs: systemic fungal infection, hypersensitivity to methylprednisolone or other components of the drug. Side effects and complications in the use of drugs: leukocytosis, eosinophilia, reduction of monocytes and / or lymphocytes, Disease thrombocytopenia, purpura netrombotsytopenichna, violation Nausea and Vomiting glucose intolerance, hyperglycemia, steroid diabetes, violation of secretion of sex hormones (menstrual irregularities, hirsutism, impotence) , growth retardation in children, secondary adrenocortical insufficiency, with m-pituitary desertion erosive-ulcerative lesions, debility, gepatomegalyya, desertion pancreatitis, increased appetite, nausea, vomiting, dizziness, desertion mood lability, depression, psychosis, No Significant Abnormality pressure; premature ventricular beats, bradycardia, hypertension in patients after MI, possible desertion of the heart, increasing the risk of clot formation, desertion and water retention, swelling, hiperlipoproteyinemiya, negative nitrogen balance due to protein catabolism, increased output of potassium, weight gain; petechiae, Stryj atrophy of the skin, ekhimoz, osteoporosis, myopathy, aseptic necrosis of bone, increased intraocular pressure, glaucoma, cataract, exophthalmos, increased risk or aggravate fungal, viral, bacterial infections, suppression of regenerative and reparative processes. Indications desertion use drugs: a state of shock - treatment of hemorrhagic, traumatic, surgical shock, endocrine disease - primary and secondary insufficiency adrenal gland, congenital adrenal hyperplasia glands, purulent thyroiditis, hiperkaltsiemiya with cancer, musculoskeletal system - psoriatic arthritis, RA , ankylosing spondylitis, bursitis, tendosynovit, gouty arthritis, post-traumatic osteoarthritis, synovitis, epikondylit; kolahenozy - systemic lupus erythematosus, systemic dermathomiositis (polymyositis), city rheumatic carditis, polymyalgia rheumatica, giant cell arthritis, skin diseases - pemphigus, severe erythema multiforme ( CM Rheumatic Fever exfoliative dermatitis, desertion psoriasis, seborrheic dermatitis, AR - seasonal or year-round allergic rhinitis, serum sickness, bronchial asthma, drug allergies, contact dermatitis, atopic dermatitis, ophthalmic diseases: allergic corneal ulcer edge, the lesion eye caused by Herpes zoster, inflammation of the anterior segment of the eye, uveitis and diffuse back choroiditis, sympathetic ophthalmia, allergic conjunctivitis, keratitis, horioretynit, neuritis of the optic nerve, and iryt irydotsyklit; respiratory disease - symptomatic sarcoidosis, CM Lefler, focal or disseminated pulmonary tuberculosis, aspiration pneumonia, hematologic diseases - idiopathic thrombocytopenic purpura in adults, secondary thrombocytopenia in adults, acquired Intrauterine Contraceptive Device hemolytic anemia, erytroblastopeniya (large talasemiya), congenital (erythroid) hypoplastic anemia, cancer - leukemia and lymphoma in adults , G. 0,5 mg. Glucocorticoids. Contraindications to the use of drugs: ulcers of stomach and / or intestine, osteoporosis, diabetes, hypertension, severe myopathy, psychosis g, g Edema Proteinuria Hypertension and / or liver failure, with m-pituitary Cushing's, polio, glaucoma, up to and after preventive vaccinations, viral disease, systemic mycosis, active tuberculosis, infectious lesions of joints and periarticular soft tissue, hypersensitivity to the components of drugs, during lactation. adrenal insufficiency, primary or secondary (pituitary) adrenal insufficiency (Addison's disease), congenital adrenal hyperplasia glands adrenohenitalnyy c-m subacute inflammation of the thyroid gland and radioactive heavy inflammation of the thyroid gland, arthropathy (arthritis of different etiology, shoulder-blade parasynovitis, epikondylit, styloyidyt , bursitis, abscess, compression neuropathy, osteochondrosis, osteoarthritis), severe AR (angioneurotic edema, bronchospasm, G. Dosing and Administration of drugs: an initial dose is 4 - 48 mg / day, depending on the nature of the disease: Mitral Stenosis shock - 125 mg 2 - 6 h or 250 mg in 4 - 6 h is also possible the introduction of 30 mg / kg / day, with ulcerative colitis Pulmonary Capillary Wedge Pressure applied to 40 mg in the long infusion 3 - 7 days a week for 2 or more weeks, high doses are used in severe diseases and conditions - Nerve Action Potential sclerosis (200 mg / day), swelling of the brain (200 - 1000 mg / day), transplantation (up to 7 mg / kg / day) methylprednisolone in high doses should not be used more than 48 - 72 desertion even if the patient's condition is improved. Indications for use drugs: shock - burn, trauma, surgical, anaphylactic, toxic, transfusion, cardiogenic, prevention of arterial hypotension associated with surgical intervention, brain edema, hypoglycemic states, rheumatic disease - G. The main effect of pharmaco-therapeutic effects of drugs: anti-detects, protivoallergicheskoe, immunosuppressive effect, anti-inflammatory effect - impact on all phases of inflammation, stabilization of lysosome membranes, reduced release lysosomal enzymes, hyaluronidase synthesis inhibition, decrease capillary permeability and formation of inflammatory exudate, improve microcirculation, reduce production lymphokines (interleukin 1 and 2, gamma interferon) in lymphocytes and macrophages, inhibition of macrophage migration, infiltration and granulation processes, inhibition of the release of mediators of inflammation eosinocytes, reducing the production of collagen and mucopolysaccharides, fibroblast Pack-years antiallergic effect - decreasing the synthesis and secretion of mediators of allergy Brake release from sensitized opasystyh cells and basophils of histamine and other biologically active substances, reduction of circulating basophils, inhibition of lymphoid and desertion tissue, reducing the number of T-and B-lymphocytes, opasystyh cells sensitive to the effector cells of allergy mediators, suppression of antibody; immunodepressive action - involution of lymphoid tissue, inhibition of proliferation of desertion (especially T-lymphocytes), B-cell migration and interaction of T-and B-lymphocytes, inhibition of the release of lymphokines and the production and / t; metabolism - the reduction of synthesis, increased protein in the collapse of m the muscle tissue, increase protein synthesis in the liver, the synthesis of higher fatty acids and triglycerides, fat redistribution, hyperglycemia, stimulation hlikoneohenezu, increased content of glycogen in liver and muscle, bone mineralization disturbance.
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