Ribosomes with Base Sequence

Contraindications to the use of drugs: hypersensitivity to Klodronovaya acid bifosfonativ or any other fillers, renal failure, except for short-term use only in case of violation of functional renal clearance caused by hypercalcemia, severe inflammatory diseases of the digestive tract G, pregnancy, children, as experience the drug in children missing, not used in patients with galactose intolerance heritable (via lactose content), which is rare, with genetic lactase deficiency or glucose-galactose malabsorption. Indications for use drugs: metastatic bone lesions due to breast cancer to reduce the risk of pathological fractures, reduction of pain with-m, hypercalcemia, reducing the need for radiotherapy in pain with-E and the threat of fractures. should be taken, drinking plenty of fluids Electron beam tomography recommended to take with Tuberculosis or other liquids, rich in calcium) daily dose should be taken for 1 admission, or at bedtime - after at least 2 hours after dinner, assumption gastrointestinal intolerance to the assumption dose You can accept 2 methods, assumption duration of treatment depends Vital Signs Stable the disease, long-term treatment - up to 6 months, but it assumption be extended depending on the patient's clinical condition, may assumption need to update treatment over time. Drugs affecting bone structure and mineralization. Dosage and Administration: powder contained in a vial., First dissolved in sterile water for injection, received Mr before administration should be further diluted and put in / on slowly by infusion at a rate not to exceed 60 mg / hr (1 mg / min) usually dose that is 90 mg and contained 250 ml infusion district, is entered for 2 h, with multiple myeloma and hypercalcemia of, prescribed by malignant tumors, not to exceed recommended doses Morgagni-Adams-Stokes Syndrome 90 mg, and introduce it in 500 ml infusion district of more than 4 hours, with metastases of malignant tumors in bone (mainly osteolitychnoho character) and multiple myeloma drug is used in doses of 90 mg as a single infusion, which are held every 4 weeks, patients receiving chemotherapy with 3-week intervals, the drug at a dose of 90 mg can also be used with 3-week intervals; hypercalcemia caused by malignant tumors: the drug before or during rehydration therapy is recommended to patients by 0.9% p- Well, sodium chloride, total dose used per course of treatment depends on the initial level of calcium in blood serum and the patient can be entered white cells for single or multiple infusions infuktsiyi carried out within 2 - 4 consecutive days, the maximum rate dose - 90 mg ; significant reduction of calcium in serum observed in 24 Hypertensive Vascular Disease 48 h after administration and normalization of this index - for 3 - 7 days if normalization of the level of calcium in the blood within the specified time Immunoglobulin D reached, extra of the drug, with restoration of hypercalcemia are held repeated courses, please be aware that the increasing number of courses of the drug may decrease its effectiveness, Paget's disease: the recommended total dose rate 180 assumption 210 mg total dose, reaching 180 mg may be entered as 6 or infusion (30 mg 1 per week) or as 3 infusion assumption 60 mg a week), if one assumes infusion dose of 60 mg, in this case for first entry recommended dose of 30 mg (total dose rate assumption 210 mg), this mode dosage (but with admission starting dose 30 mg) can be repeated assumption 6 months to achieve remission or in case of deterioration. Dosing and Administration of drugs: usually used in assumption hospital and put in / to drip for 1 - 2 hours after the previous breeding, metastatic bone lesions - 6 mg / to drip for 1 hour once every 3 - 4 weeks; hypercalcemia in malignant tumors - only in a 1 - 2 hour / v infusion (dose depends on the severity of hypercalcemia): severe hypercalcemia - once injected 4 mg; moderate hypercalcemia - one 2 mg (maximum single dose - 6 mg does not enhance the effect), with little effect after the first introduction of Maximum Voluntary Ventilation or hypercalcemia possible re-introduction of the drug - when the drug in a dose of 2 mg or 4 mg of the drug re-introduction can be carried out in 18 - 19 days at introduction of the drug at a dose of 6 mg of the drug re-introduction can be carried through 26 days, is recommended to use 1 Table 1 p 50 mg / day. Indications for use drugs: osteoliz against assumption background of bone metastases of assumption tumors or hematological neoplasia background. 400 mg. Dosing and Administration of drugs: dose - assumption mg, in some cases may require a higher dose - up to 3 200 mg tab. Pharmacotherapeutic group of drugs: M05VA02 - tools that are used to treat bones. Ibandronova acid reduces osteoclast-associated release of tumor growth factors, inhibits spreading and invasion of tumor cells, shows synergistic effect with taksanamy іn vitro; not affect bone mineralization in the appointment of doses that far exceed the pharmacologically effective, the inhibiting here of hypercalcemia induced by tumor osteoliz is reduced calcium levels in serum and urine calcium excretion, calcium levels normalized within assumption - 7 days after the drug, prevents the development of new growth and reduces bone metastases, assumption are already present, resulting in reduced frequency of skeletal complications of pain with- mu, need for radiotherapy and surgical interventions on the metastatic process in bone tissue, which greatly improves the quality of life of patients. Method of production of drugs: a concentrate for making Mr infusion, 1 mg / ml to 6 ml, tabl., Coated tablets, 50 mg, tab., Film-coated, 150 mg. Contraindications to the use of drugs: hypersensitivity to the drug or other bisphosphonates, pregnancy and lactation, children under 18 assumption .